I hope you’ve been well! I was wondering if you could help me with this critical review assignment for these two articles? Please let me know if you can do this 🙂

The written full assignment will be completed independently.  Please integrate and provide critical review about two assigned papers. 

  1. Chakrabarti R, Celià-Terrassa T, Kumar S, et al. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal nicheScience. 2018;360(6396). 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881440/
  1. Kumar, S., Srivastav, R.K., Wilkes, D.W. et al. Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer. Oncogene 38, 2092–2107 (2019).
https://www.nature.com/articles/s41388-018-0562-z

The instructions are below (and attached) to this email.

The full assignment is a short essay, in a News and Views style (Nature). The essay is limited to 6 pages double-spaced, Times 12 point font. 

The essay should include, 

Introduction

The introduction should present a cohesive information and a detailed background about the key concepts. Please use recent literature to support your introduction. (1-2 Pages) 

Hypothesis/ Goal

Hypothesis should specify each hypothesis and draw connection between two hypotheses. (1/2- 1 page) 

Discussion

Discussion should include the interpretation of key experimental results, incorporation of take-home messages. Please avoid detailed summary of the results and the figures, your interpretation and discussion will the key in this section. 

Provide a smooth transition between two papers, support your discussion with the literature

Provide a discussion how research papers contributed to the field, how they complement or contrast with each other. 

Identify the open/ unanswered questions and indicate the experimental approaches that

could be used to answer the questions. (what open questions remain even with the two

papers combined?)    (3-4 pages) 

Provide a brief conclusion to your review. 

Reference

Citations must be referenced using the format found in the journal Cell (full references).

References and figures are not included in the page count, however, a 10%

penalty will be assessed for each extra half page or page over the recommended

guideline. Late assignments are docked 10% per day.